Paroxysmal Nocturnal Hemoglobinuria : From Bench to Bedside

Paroxysmal Nocturnal Hemoglobinuria: From Bench to Bedside, reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody, eculizumab. But while the PIGA gene has been identified for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure. "