Advances in Family-Based Association Analysis : 15 Years of Practical Experience with the Original Transmission Disequilibrium Test

This special issue celebrates the anniversary of the seminal publication introducing the transmission disequilibrium test (TDT) as a method for testing linkage and association in family data. It features a series of reviews and methodological papers by noted researchers in the field, each of whom has made advances in family-based association testing. Anyone performing family-based association testing and those who wish to learn more about the history regarding the development of the TDT will appreciate the additional investigations of the TDT statistic presented in this issue.