Accounts in Drug Discovery : Case Studies in Medicinal Chemistry

Accounts in Drug Discovery describes recent case studies in drug discovery and in particular how problems were overcome. In particular, the case studies were selected to cover a broad range of topics including: diverse disease areas (oncology, cardiovascular, metabolic disorders, inflammation, anti-infective agents, GI and urinary disorders); first-in-class vs. follow on compounds; leads compounds that were derived from multiple sources including screening, structure-based design, and follow-ons; successful marketed drugs as well as those that failed prior to or at registration that are rarely communicated in such a compendium. The issues to be addressed, both in Discovery and in the Clinic, will survey those commonly faced by researchers in the field including: metabolism and pharmacokinetics, toxicology, pharmaceutics, and proof of concept for the biological target.